After graduating in Fine Arts from the Thrissur School of Drama in the 1980s, he spent two years in Europe doing theater and drama. Murali aimed at drama and stage in the film. He returned home as an associate director on Adoor Gopalakrishnan’s Kathapurushan and collaborated on friend and classmate Shyamaprasad’s films.
In 1995, Murali made his debut in Malayalam cinema with the film ‘Mududu’ directed by Ambili. His role in the 2004 film Bhavam was notable. Bhavthal directed by Satish Menon also starred Jyotirmayi, Mita Vashishth and others. In 2005, the lead role was available in Satish Paul’s Fingerprint. In the same year, Ranjith also played a good role in Chandratsavam. Then he acted in many films like Ritu, Our Lady of Lourdes.